Roy P. Planalp

Associate Professor

Inorganic Chemistry
Department of Chemistry
University of New Hampshire
Durham, NH 03824-3598 U.S.A.
Phone: 603-862-2471
Fax: 603-862-4278
roy.planalp(at)unh.edu

Education and Achievements

  • S.B., 1979, Massachusetts Institute of Technology
  • Ph.D., 1983, University of California at Berkeley
  • Alexander von Humboldt Research Fellow, 1984-1985, Universität Freiburg, Germany
  • Research Associate, 1985-1987, University of Illinois at Urbana-Champaign
  • Visiting Scientist, 1994-1995, Inorganic and Radioimmune Chemistry Section, Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland

Courses Taught

  • 903-Advanced Inorganic Chemistry I
  • 775-Advanced Inorganic Chemistry Laboratory
  • 947-Inorganic Biochemistry
  • 904-Organometallic Chemistry

Research Interests

Synthesis, structure, aqueous speciation and reactivity of metal coordination complexes. Synthetic and physical inorganic chemistry applied to problems in the life sciences and environmental sciences.

More on Research Interests...

Current Group Members

Lea Nyiranshuti
Mahmoud Abdalrahman
Luke Fulton
Shannon Sides
Kelsey Calhoun

Former Group Members

2008-2013-Justin Massing, Ph.D.
Thesis: Design, Synthesis, and Formation Constant Studies of Labile Ligands for a Novel Metal-Ion Sensor

2010-2013-Steve 'Kyle' Burton, M.S.
Thesis: Metal-Ion Buffer Systems for Study of Metalloenzymes

2005–2008-Joonhyung Cho, M.S.
Now at Intellectual Property Associate, LSU Ag Center, Baton Rouge, LA
Thesis: I. Complexation of Fe(II), Ni(II), Cu(II) and Zn(II) by Hexadentate Tripodal Aminopyridyl Chelators. II. The Potential of Curcumin in Medicine: Synthesis and Iron Coordination Chemistry of Curcuminoids

2003–2007 Dan P. Kennedy, Ph.D.
Now a temporary lecturer, Univ. of New England
Thesis: I. The synthesis and coordination chemistry of novel 1,1,1-tris(aminomethyl)ethane (tame) derived ligands and their use as size selective fluorescent Zn(II) sensors.  II. The synthesis of strongly- and weakly-binding ligands with N, O, and S-donor groups to be used as receptors in fluorescent ratiometric indicators for transition metal ions 

2003–2006 Matt Childers – M.S.
Now at Merck Boston
Thesis: I. Complexation of Fe(II), Co(II), Ni(II) and Cu(II) by hexadentate tripodal aminopyridyl chelators II. Binding preferences for Zn(II) relative to Ni(II) and Cu(II) in novel tetradentate aminopyridyl chelators

2004–2006 Allison Lindell – MS
Thesis: Synthetic approaches to cis, cis-1,3,5-triaminocyclohexane (TACH) and TACH-based ligands

2000-2002-Ann M. Przyborowska – MS
Now at UMass Medical Center, Worcester, MA
Thesis: Complexation of Fe(II), Fe(III), Cu(II), and Zn(II) by hexadentate tripodal aminopyridyl chelators and the role of oxidative dehydrogenation in iron complexes

1996-2000 Gyungse Park (Ph.D.)
Now an Associate Professor, School of Science and Technology, Kunsan National University, Republic of Korea
Thesis: Transition metal complexes of novel ligands derived from the cis,cis-1,3,5-triaminocyclohexane (tach) framework: Structural and biological studies

1995-1996 Neng Ye, MS
Employed by Aspen Co., Boxboro, MA
Thesis: Divalent Transition-Metal Complexes of Novel Hexadentate Ligands Based on cis, cis-1,3,5-Triaminocyclohexane: Synthesis and Structures

1994-1995 Megan T. Tran- MS
Employed by Wyeth-Ayerst Pharmaceuticals, Princeton NJ
Thesis: Synthesis of Novel Vanadium and Titanium Complexes of the Atrane-Family Alkoxide Ligand Tris(2-methyl-2-propoxide)amine and their Reactions with Organic Cooxidants

1993-1995 Russell F. Graceffa- MS
Employed by Arqule Pharmaceuticals, Princeton NJ
Thesis: The Synthesis of Polydentate Alkoxide Ligands and Reactions with Early Transition Metals

Recent and Significant Publications

[1]Osambo, J.; Seitz, W.; Kennedy, D.; Planalp, R.; Jones, A.; Jackson, R.; Burdette, S. Fluorescent Ratiometric Indicators Based on Cu(II)-Induced Changes in Poly(NIPAM) Microparticle Volume. Sensors 2013, 13, 1341-52.

[2]Yao, S.; Jones, A. M.; Du, J.; Jackson, R. K.; Massing, J. O.; Kennedy, D. P.; Bencivenga, N. E.; Planalp, R. P.; Burdette, S. C.; Seitz, W. R. Intermolecular approach to metal ion indicators based on polymer phase transitions coupled to fluorescence resonance energy transfer. Analyst, 2012, 137, 4734-41.

[3]Du, J.; Yao, S.; Seitz, W. R.; Bencivenga, N. E.; Massing, J. O.; Planalp, R. P.; Jackson, R. K.; Kennedy, D. P.; Burdette, S. C. A ratiometric fluorescent metal ion indicator based on dansyl labeled poly(N-isopropylacrylamide) responds to a quenching metal ion. Analyst, 2011, 136, 5006-11.

[4]Hatcher, H.; Planalp, R.; Cho, J.; Torti, F.; Torti, S. Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences (CMLS) 2008, 65, 1631-52.

[5]Childers, M. L.; Cho, J.; Regino, C. A. S.; Brechbiel, M. W.; DiPasquale, A. G.; Rheingold, A. L.; Torti, S. V.; Torti, F. M.; Planalp, R. P. Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators. Journal of Inorganic Biochemistry 2008, 102, 150-6.

 

Updated 4/17/2015