Gary R. Weisman
Education and Achievements
- B.S., 1971, University of Kentucky
- Ph.D., 1976, University of Wisconsin at Madison
- Postdoctoral Research Associate, 1976-77, University of California, Los Angeles
- Visiting Associate Professor, 1986, University of Wisconsin at Madison
- Visiting Fellow, 1987, University of Bristol, England
- Visiting Fellow, 1998, University of Bristol, England
- Wilsmore Fellow, University of Melbourne, 2002
- Visiting Fellow, Australian National University, 2005
- Visiting Professor, University of Melbourne, Australia, 2005
- Excellence in Teaching Award - UNH College of Engineering and Physical Sciences, 1995
- Excellence in Teaching Award - UNH College of Engineering and Physical Sciences, 2009
Physical organic chemistry; Synthetic organic chemistry; Synthesis, reactions, special properties and coordination chemistry of amines and polyamines and derivatives; Ligand design and synthesis; Biomedical applications of coordination complexes; Supramolecular chemistry; Conformational analysis; In/out isomerism and homeomorphic isomerization of bicyclic molecules; Use of NMR in structural and conformational analysis of organic and metallo-organic compounds.
Current Research Interests
Much of our research is presently focused upon investigation of cyclic and polycyclic polyamines. With Professor Ed Wong, we are carrying out investigations of the coordination chemistry of a variety of novel polyamine ligands. Polyaza molecules including aminals, amidines, orthoamides, and ureas have proven to be useful synthetic intermediates for the preparation of macrocyclic and polycyclic polyamines, pendant-arm derivatives, and bis-(macrocyclic polyamine) molecules. Novel tricyclic bisamidine ligands have also been studied. With Professor Wong and Professor Carolyn J. Anderson and her group at the University of Pittsburgh School of Medicine, we are investigating the use of "cross-bridged" tetraamines (see 1-3 below) in radiopharmaceutical applications.
Selected Publications since 2000
“A Trimethylene versus an Ethylene Cross-bridged Tetraazamacrocycle and in vitro/in vivo Comparisons of their Copper(II) Complexes”, Antoinette Y. Odendaal, Riccardo Ferdani, Ashley L. Fiamengo, Thaddeus J. Wadas, Gary R. Weisman,* Edward H. Wong,* Carolyn J. Anderson, Katie J. Heroux, James A. Golen, and Arnold L. Rheingold, Inorganic Chemistry, 2011, 50, 3078–3086.
“Comparative Structural Coordination Chemistry of Two Tricyclic Bisamidines”, Jingwei Li, Daniel W. Widlicka, Kerry Fichter, David P. Reed, Gary R. Weisman, Edward H. Wong, Antonio DiPasquale, Katie J. Heroux, James A. Golen, and Arnold L. Rheingold, Inorganica Chimica Acta, 2010, 364, 185-194.
“Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease”, Thaddeus J. Wadas, Edward H. Wong, Gary R. Weisman, and Carolyn J. Anderson*, Chemical Reviews, 2010, 110, 2858–2902 (comprehensive review).
“A new phosphonate pendant-armed cross-bridged tetraamine chelator accelerates copper(II) binding for radiopharmaceutical applications”, Dannon J. Stigers, Riccardo Ferdani, Gary R. Weisman, Edward H. Wong, Carolyn J. Anderson, James A. Golen, Curtis Moore, and Arnold L. Rheingold, Dalton Transactions, 2010, 39, 1699-1701.
“Cross-bridged macrocyclic chelators for stable complexation of copper radionuclides for PET imaging”, Carolyn J. Anderson, Thaddeus J. Wadas, Edward H. Wong, and Gary R. Weisman, Q. J. Nucl. Med. Mol. Imaging, 2008, 52, 185-92 (review).
“The Long and Short of It: The Influence of N-Carboxyethyl versus N-Carboxymethyl Pendant Arms on in vitro and in vivo Behavior of Copper Complexes of Cross-bridged Tetraamine Macrocycles”, Katie J. Heroux, Katrina S. Woodin, David J. Tranchemontagne, Peter C. B. Widger, Evan Southwick, Edward H. Wong, Gary R. Weisman, Sterling A. Tomellini, Thaddeus J. Wadas, Carolyn J. Anderson, Scott Kassel, James A. Golen and Arnold L. Rheingold, Dalton Transactions, 2007, 2150–2162.
“Synthesis, Characterization and In Vivo Studies of Cu(II)-64-Labeled Cross-Bridged Tetraazamacrocycle-amide Complexes as Models of Peptide Conjugate Imaging Agents”, Jennifer E. Sprague, Yijie Peng, Ashley L. Fiamengo, Katrina S. Woodin, Evan A. Southwick, Gary R. Weisman, Edward H. Wong, James A. Golen, Arnold L. Rheingold, and Carolyn J. Anderson, Journal of Medicinal Chemistry, 2007, 50, 2527-2535.
“Copper Chelation Chemistry and its Role in Copper Radiopharmaceuticals”, Thaddeus J. Wadas, Edward H. Wong, Gary R. Weisman, and Carolyn J. Anderson, Current Pharmaceutical Design, 2007, 13, 3-16 (review).
“Copper-based ATRP Catalysts of Very High Activity Derived from Dimethyl Cross-bridged Cyclam”, Nicolay V. Tsarevsky, Wade A. Braunecker, Wei Tang, Samuel J. Brooks, Krzysztof Matyjaszewski, Gary R. Weisman, and Edward H. Wong, Journal of Molecular Catalysis A: Chemical 2006, 257, 132-140.
“Kinetic Inertness and Electrochemical Behavior of Copper(II) Tetraazamacrocyclic Complexes: Possible implications for in vivo Stability”, Katrina S. Woodin, Katie J. Heroux, C. Andrew Boswell, Edward H. Wong, Gary R. Weisman, Weijun Niu, Sterling A. Tomellini, Carolyn J. Anderson, Lev N. Zakharov, and Arnold L. Rheingold, European Journal of Inorganic Chemistry, 2005, 4829-4833.
“Preparation and Biological Evaluation of Copper-64-labeled Tyr3-octreotate Using a Cross-Bridged Macrocyclic Chelator”, Jennifer E. Sprague, Yijie Peng, Xiankai Sun, Gary R. Weisman, Edward H. Wong, Samuel Achilefu, and Carolyn J. Anderson, Clinical Cancer Research, 2004, 10, 8674-8682.
“Inside or outside a Ligand Cleft? Synthetic, Structural, and Kinetic Inertness Studies of Zinc, Cadmium, and Mercury Complexes of Cross-bridged Cyclam and Cyclen”, Weijun Niu, Edward H. Wong, Gary R. Weisman , Daniel C. Hill, David J. Tranchemontagne, Kim-Chung Lam, Roger D. Sommer, Lev N. Zakharov, and Arnold L. Rheingold, Dalton Transactions, 2004, 3536-3547.
“Structural and Dynamic Studies of the Zinc, Gallium, and Cadmium Complexes of Dicarboxylate Pendant-armed Cross-bridged Cyclen”, Weijun Niu, Edward H. Wong, Gary R. Weisman, Yijie Peng, Carolyn J. Anderson, Lev N. Zakharov, James A. Golen and Arnold L. Rheingold, European Journal of Inorganic Chemistry, 2004, 3310-3315.
“Comparative In Vivo Stability of Copper-64-Labeled Cross-Bridged and Conventional Tetraazamacrocyclic Complexes”, C. Andrew Boswell, Xiankai Sun, Weijun Niu, Gary R. Weisman, Edward H. Wong, Arnold L. Rheingold, and Carolyn J. Anderson, Journal of Medicinal Chemistry, 2004, 47, 1465-1474.
“Copper(II) and zinc(II) Complexes of Amide Pendant-Armed Cross-Bridged Tetraamine Ligands”, Weijun Niu, Edward H. Wong, Gary R. Weisman, Lev. N Zakharov, Chris D. Incarvito, and Arnold. L. Rheingold, Polyhedron, 2004, 23, 1019-1025.
“A Sterically-Hindered Tricyclic Biimidazoline Ligand which is also a Precursor to a Novel Tetramethyl-Cyclen”, Daniel W. Widlicka , Edward H. Wong, Gary R. Weisman, Roger D. Sommer, Christopher D. Incarvito, and Arnold L. Rheingold, Inorganica Chimica Acta, 2002, 341C, 45-53.
“Radiolabeling and In Vivo Behavior of Copper-64-Labeled Cross-Bridged Cyclam Ligands”, Xiankai Sun, Melinda Wuest, Gary R. Weisman, Edward H. Wong, David P. Reed, C. Andrew Boswell, Ramunas Motekaitis, Arthur E. Martell, Michael J. Welch, and Carolyn J. Anderson, Journal of Medicinal Chemistry, 2002, 45, 469-477.
“Gallium(III) and Indium(III) Complexes of Crossed-Bridged Tetraamine Ligands”, Weijun Niu, Edward H. Wong,* Gary R. Weisman, Roger D. Sommer, and Arnold L. Rheingold, Inorganic Chemistry Communications, 2002, 5, 1-4.
“1,4,7,10-Tetraazacyclododecane”, David P. Reed and Gary R. Weisman, Organic Syntheses, 2002, 78, 73-81; Coll. Vol. 10, p. 667, 2004.
“A Preconstrained Tricyclic Biimidazoline Ligand Adaptable to Diverse Coordination Modes”, Daniel W. Widlicka , Edward H. Wong, Gary R. Weisman, Kim-Chung Lam, Roger D. Sommer, Christopher D. Incarvito, Arnold L. Rheingold, Inorganic Chemistry Communications, 2000, 3, 648-652.
“Synthesis and Characterization of Cross-Bridged Cyclams and Pendant-Armed Derivatives, and Structural Studies of their Copper(II) Complexes”, Edward H. Wong, Gary R. Weisman, Daniel C. Hill, David P. Reed, Mark E. Rogers, Jeffrey S. Condon, Maureen A. Fagan, Joseph C. Calabrese, Kin-Chung Lam, Ilia A. Guzei, and Arnold L. Rheingold, Journal of the American Chemical Society, 2000, 122, 10561-10572.
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