Edward H. Wong
Education and Achievements
- B.S., 1968, University of California at Berkeley
- Ph.D., 1975, Harvard University
- Postdoctoral Research Associate, 1975-76, University of California at Los Angeles
- Visiting Professor and St. Mary's Fellow, 1986-1987, University of Durham, England
- Visiting Professor, 1994, University of California at Berkeley
Transition and main group metal complexes of cross-bridged tetraamine macrocycles and their applications in radiopharmaceutical and bioinorganic chemistry. Bisamidine d- and f-metal complexes and their coordination and reaction chemistry.
Current Research Interests
We are participating in a three-way collaborative effort (with Prof. Gary R. Weisman here at UNH, and Professor Carolyn J. Anderson at the Washington University St. Louis Medical School) to develop new radiopharmaceuticals for both diagnostic and therapeutic applications. Specifically, cross-bridged tetraamine macrocycles (Figure 1) have been shown to form complexes with specific metal cations which are remarkably inert kinetically. Attachment of ionizable pendant arms to these cross-bridged ligands have further enhanced this stability. A dicarboxylate-armed cross-bridged cyclam (Figure 2) has shown promise in in vivo animal studies upon labeling with Copper-64, one of several potentially useful copper radioisotopes. The resulting complex has superior clearance characteristics as well as significantly enhanced stability towards radio-metal loss by transchelation as well as reductive processes (Figure 3).
Recent efforts are focused on preparation of bioconjugates to tumor receptor site analogues for targeted delivery of radio-copper which have yielded encouraging results. We have also successfully prepared Gallium and Indium complexes of our cross-bridged ligands because both Ga and In radioisotopes have applications as radiopharmaceutical imaging agents.
UNH participants in this NIH-funded project carry out the design and synthesis of new cross-bridged ligands, their complexation to Cu(II), Ga(III), and In(III) cations, elucidation of spectral and structural properties of these complexes, as well as determination of their kinetic inertness using spectroscopic and analytical methodologies. Group research members attain expertise in organic and inorganic syntheses as well as proficiency in both analytical and kinetic procedures.
In collaboration with Prof. Gary R. Weisman, we are also engaged in the design and synthesis of novel Bisamidine ligands that have a variety of coordination modes with both d- and f-metals. Exploration of both the reaction and catalytic chemistry of these complexes are of interest.
Professor: Edward H. Wong
Selected Recent Publications
Widlicka, D.W.; Wong, E.H.; Weisman, G.R.; Lam, K.C.; Sommer, R.D.; Incarvito, C.D.; and Rheinghold, A.L. "A Preconstrained tricyclic biimidazoline ligand adaptable to diverse coordination modes", Inorg. Chem. Commun. 2000, 3, 648.
Wong, E.H.; Weisman, G.R.; Hill, D.C.; Reed, D.P.; Rogers, M.E.; Condon, J.P.; Fagan, M.A.; Calabrese, J.C.; Lam, K.-C.; Guzei, I.A.; Rheingold, A.L. "Synthesis and Characterization of Cross-Bridged Cyclams and Pendant-Armed Derivatives and Structural Studies of their Copper(II) Complexes", J. Am. Chem. Soc., 2000, 122, 10561.
Sun, X.; Johnson, D. W.; Caulder, D. L.; Raymond, K. N.; and Wong, E. H. "Rational Design and Assembly of Supramolecular M2M'3L6 Clusters using Incommensurate Symmetry", J. Am. Chem. Soc., 2001, 123, 2752.
Sun, X.; Johnson, D.W.; Raymond, K.N.; and Wong, E.H. "A Silver-linked Supramolecular Cluster Encapsulating a Cesium Cation", Inorg. Chem., 2001, 40, 4504.
Boswell, C. A., X. Sun, M. Wang, B. Ramos, G. R. Weisman, E. H. Wong, and C. J. Anderson, "Relationship between Reduction Potential and in vivo Stability of Copper-Azamacrocyclic Complexes", J. Label. Compd. Radiopharm., 2001; S784-S786.
Niu, W.; Wong, E.H., Weisman, G.R.; Sommer, R.D.; and Rheingold, A.L. "Gallium(III) and Indium(III) complexes of Cross-bridged Tetraamine Ligands, Inorg. Chem. Commun. 2002, 5, 1.
Sun, X.; Wuest, M.; Weisman, G.R.; Wong, E.H.; Reed, D.P.; C. Boswell, A.; Motekaitis, R.; Martell, A.E.; Welch, M.J.; and Anderson, C.J. "Radiolabeling and In Vivo Behavior of Copper-64-Labeled Cross-Bridged Cyclam Ligands" J. Med. Chem., 2002, 45, 469.
Widlicka, Daniel W., Edward H. Wong, Gary R. Weisman, Roger D. Sommer, Christopher D. Incarvito , and Arnold L. Rheingold," A Sterically-hindered Tricyclic Biimidazoline Ligand which is also a Precursor to a Novel Tetramethyl-Cyclen" Inorg. Chim. Acta, 2002, 341, 45-53.
C. Andrew Boswell, Xiankai Sun, Weijun Niu, Gary R. Weisman, Edward H. Wong, Arnold L. Rheingold, Carolyn J. Anderson, "Comparative in vivo Stability of Copper-64-Labeled Cross-Bridged and Conventional Tetraazamacrocyclic Complexes" J. Med. Chem. 2004, 47, 1465-1474.
Weijun Niu, Edward H. Wong, Gary R. Weisman, Lev N. Zakharov, Chris D. Incarito and Arnold L. Rheingold, "Copper(II) and Zinc(II) Complexes of Amide Pendant-armed Cross-bridged Tetraamine Ligands" Polyhedron 2004, 23, 1019-1025.
Weijun Niu, Edward H. Wong, Gary R. Weisman, Yijie Peng, Carolyn J. Anderson, Lev N. Zakharov, James A. Golen and Arnold L. Rheingold, "Structural and Dynamic Studies of the Zinc, Gallium, and Cadmium Complexes of Dicarboxylate Pendant-armed Cross-bridged Cyclen" Euro. J. Inorg. Chem. 2004, 3310-3315.
Niu, Weijun, Edward H. Wong, Gary R. Weisman, Daniel C. Hill, David J. Tranchemontagne, Kim-Chung Lam, Robert D. Sommer, Lev N. Zakharov, Arnold L. Rheingold, "Inside or Outside a Ligand Cleft? Synthetic, Structural, and Kinetic Inertness Studies of Zinc, Cadmium, and Mercury Complexes of Cross-bridged Cyclam and Cyclen" Dalton Transactions, 2004, 21, 3536-3547.
Jennifer E. Sprague, Yijie Peng, Xiankai Sun, Gary R. Weisman, Edward H. Wong, Samuel Achilefu, Carolyn J. Anderson, "Preparation and Biological Evaluation of Copper-64-Labeled Tyr3-Octreotate Using a Cross-Bridged Macrocyclic Chelator" Clinical Cancer Research, 2004, 19(24), 8674-8682.
C. Andrew Boswell, Paul McQuade, Gary R. Weisman, Edward H. Wong , and Carolyn J. Anderson, "Optimization of labeling and metabolite analysis of copper-64-labeled azamacrocyclic chelators by radio-LC-MS", Nucl. Med. Biol. 2005, 32, 29-38.
Katrina S. Woodin, Katie J. Heroux, C. Andrew Boswell, Edward H. Wong, Gary R. Weisman, Weijun Niu, Sterling A. Tomellini, Carolyn J. Anderson, Lev N. Zakharov, and Arnold L. Rhenigold, "Kinetic inertness and electrochemical behavior of copper(II) tetraazamacrocyclic complexes: possible implications for in vivo stability" Eur. J. Inorg. Chem. 2005, 4829-4833.
Xiaoxuan Shen, C. Andrew Boswell, Edward H. Wong, Gary R. Weisman, Carolyn J. Anderson, and Sterling A. Tomellini, "Investigation of copper-azamacrocyclic complexes by high-performance liquid chromatography" Biomed. Chrom 2006, 20, 37-47.
Dannon J. Stigers, Riccardo Ferdani, Gary R. Weisman, Edward H. Wong, Carolyn J. Anderson, James A. Golen, Curtis Moore and Arnold L. Rheingold, "A new phosphonate pendant-armed cross-bridged tetraamine chelator accelerates copper(ii) binding for radiopharmaceutical applications," Dalton Trans. 2010, 39, 1699-1701.
Thaddeus J. Wadas, Edward H. Wong, Gary R. Weisman and Carolyn J. Anderson, "Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease," Chem. Rev. (Washington, DC, U. S.), 2010, 110, 2858.
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