Harish Vashisth

Harish Vashisth, Assistant Professor

in
Office: 
Kingsbury Hall W323
Phone: 
(603) 862-2483

Education

Ph.D., Drexel University, Philadelphia, PA, 2010
B.Tech., National Institute of Technology, Warangal, AP India, 2005
Research Interests: 
  • Computational Biophysics, Biomolecular Simulations, Molecular Transport, Cell Signaling via Membrane Proteins
Courses Taught: 
  • CHE604: Chemical Engineering Thermodynamics
  • CHE923: Advanced Chemical Engineering Thermodynamics
Recent Publications: 
  • Harish Vashisth, Georgios Skiniotis, and Charles L. Brooks III, “ Collective variable approaches for single molecule flexible fitting and enhanced sampling,” Chem. Rev. 114:3353-3365 (2014). (Special Issue on Single Molecule Mechanisms and Imaging)
  • Harish Vashisth, Andrew J. Storaska, Richard R. Neubig, and Charles L. Brooks III, “Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule,” ACS Chem. Biol. 8:2778-2784 (2013). (Featured by Journal as Top 20 most-read papers, Oct.-Nov. 2013).
  • Harish Vashisth and Cameron F. Abrams, “All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element,” Proteins  81:1017-1030 (2013). (Featured on Journal Cover)
  • Harish Vashisth, Georgios Skiniotis, and Charles L. Brooks III, “Enhanced sampling and overfitting analyses in structural refinement of nucleic acids into electron microscopy maps,” J. Phys. Chem. B 117:3738-3746 (2013).
  • Harish Vashisth and Charles L. Brooks III, “Conformational sampling of maltose-transporter components in Cartesian collective variables is governed by the low-frequency normal modes,” J. Phys. Chem. Lett. 3:3379-3384 (2012)
  • Harish Vashisth, Georgios Skiniotis, and Charles L. Brooks III, “Using enhanced sampling and structural restraints to refine atomic structures into low-resolution electron microscopy maps,” Structure 20:1453-1462 (2012) Featured by Journal as Top 20 Most-read Papers
  • Harish Vashisth, Luca Maragliano, and Cameron F. Abrams, “DFG-flip in the insulin receptor kinase is facilitated by a helical intermediate state of the activation loop,” Biophys. J. 102:1979-1987 (2012).
  • Bethany S. Strunk, Cherisse Rae Loucks, Min Su, Harish Vashisth, Shanshan Cheng, Justin Schilling, Charles L. Brooks III, Katrin Karbstein, and Georgios Skiniotis, “Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates,” Science 333:1449-1453 (2011). (Highlighted in News and Views, Nat. Struct. Mol. Biol.)
  • Harish Vashisth and Cameron F. Abrams, “All-atom structural models for complexes of insulinlike growth factors IGF1 and IGF2 with their cognate receptor,” J. Mol. Biol. 400:645-658 (2010).
  • Harish Vashisth and Cameron F. Abrams, “Docking of insulin to a structurally equilibrated insulin receptor ectodomain,” Proteins 78:1531-1543 (2010). (Featured on Journal Cover)
  • Harish Vashisth and Cameron F. Abrams, “Ligand escape pathways and (un)binding free energy calculations for the hexameric insulin-phenol complex,” Biophys. J. 95:4193-4204 (2008).